Sonoluminescence is the term used to describe the emission of light from a violently collapsing bubble. Sonoluminescence ("light from sound") is the result of extremely nonlinear pulsations of gas/vapor bubbles in liquids when subject to sufficiently high amplitude acoustic pressures. In a single collapse, a bubble's volume can be compressed more than a thousand-fold in the span of less than a microsecond. Even the simplest consideration of the thermodynamics yields pressures on the order of 10,000 ATM. and temperatures of at least 10,000 K. On the face of things, it is not surprising that light should be emitted from such an extreme process. Since 1990 (the year that Gaitan discovered light from a single bubble) there has been a tremendous amount of experimental and theoretical research in stable, single-bubble sonoluminescence. Yet there remain four fundamental mysteries associated with this phenomenon: 1) the light emission mechanism itself; 2) the mechanism for anomalous mass flux stability; 3) the disappearance of the bubble at some critical acoustic pressure; and 4) the appearance of quasiperiodic and chaotic oscillations in the flash timing. Gravity, in the context of the buoyant force, is implicated in all four of these unexplained phenomena. We are developing microgravity experiments probing the effect of gravity on single bubble sonoluminescence. By determining the stability boundaries experimentally in microgravity, and measuring not only light emission but mechanical bubble response, we will be able to directly test the unambiguous predictions of existing theories. By exploiting the microgravity environment we will gain new knowledge impossible to obtain in earth-based labs which will enable explanations for the above mysteries. We will also be in a position to make new discoveries about bubbles which emit light.